主要从事有机小分子化合物在疾病诊断与治疗中的应用。入选江苏省“333工程”第三层次、江苏省“青蓝工程”优秀青年骨干教师、江苏省双创计划“科技副总”等计划；《药学研究》青年编委；国家自然科学基金、荷兰研究理事会（Dutch Research Council, NWO）项目评审专家。

近5年以通讯作者在Coordin Chem Rev、Chem Eng J、Analytical Chemistry、Small、Biomaterials、Chem Sci、Biosens Bioelectron、AHM、ACS App Mater Inter等期刊发表SCI学术论文五十余篇；申请专利10余项，授权6项。参与研发的抗肿瘤1类新药安奈克替尼（TQ-B3101/Unecritinib）成功上市。

指导本科生获得挑战杯全国竞赛江苏省二等奖、全国大学生生命科学创新创业大赛二等奖；指导研究生获得江苏省优秀学位论文（2人）、国家奖学金（9人次）、江苏省优秀毕业生（2人）、校长奖学金（1人）等。

1. 有机小分子诊疗探针；

2. 抗肿瘤新药发现研究；

3. 原料药和生物化工产品工艺开发。

主持国家自然科学基金面上项目和青年项目、江苏省自然科学基金等项目。

1. Self-assembly strategies of organic small-molecule photosensitizers for photodynamic therapy. Coordination Chemistry Reviews, 2024, 510, 215863

2. Visualization of the Ferroptosis in Atherosclerotic Plaques with Nanoprobe Engineered by Macrophage Cell Membranes. Anal. Chem. 2024, 96, 281-291

3. A sulfatase-activatable AIEgen nanoprobe for inhalation imaging-guided surgical excision of lung cancer. Chemical Engineering Journal, 2022, 428, 132514

4. Light-controlled fluorescent probes for precisely monitoring brain amyloid-β aggregates in Alzheimer‘s disease. Chemical Engineering Journal, 2022, 446, 137385

5. Differentiating Aβ40 and Aβ42 in amyloid plaques with a small molecule fluorescence probe. Chemical Science, 2020, 11: 5238-5245

6. Near-Infrared Light-Driven Nanoparticles for Cancer Photoimmunotherapy by Synergizing Immune Cell Death and Epigenetic Regulation. Small, 2023, 2309202

7. Phototheranostic Agents Based on Nonionic Heptamethine Cyanine for Realizing Synergistic Cancer Phototherapy. Adv. Healthcare Mater. 2023, 2202817

8. Homotypic targeting upconversion nano-reactor for cascade cancer starvation and deep-tissue phototherapy. Biomaterials, 2020, 235,119765

9. A dual-site fluorescent probe for direct and highly selective detection of cysteine and its application in living cells. Biosensors and Bioelectronics, 2017, 92, 583-588

10. Organic small molecule-based photothermal agents for cancer therapy: Design strategies from single-molecule optimization to synergistic enhancement. Coordination Chemistry Reviews, 2022, 464, 214564